Human GITR Protein, His Tag, Avi Tag
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产品编号
KMP3094
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别名
糖皮质激素诱导的肿瘤坏死因子受体相关蛋白, Human GITR Protein, His Tag, Avi Tag, GITR
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规格
- 50ug
- 100ug
- 200ug
产品介绍
| Alias | 糖皮质激素诱导的肿瘤坏死因子受体相关蛋白, Human GITR Protein, His Tag, Avi Tag, GITR |
| Catalog Number | KMP3094 |
| Product Description | The Human GITR Protein(KMP3094) is produced in HEK293 Cells. The target gene encoding the Human TNFRSF18 (NP_683700.1) (Met1-Glu161) is expressed with a C-terminal polyhistidine tag followed by an Avi tag. The expressed protein is biotinylated in vivo by the Biotin-Protein ligase (BirA enzyme) which is co-expressed. |
| Molecular Name | GITR |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | GITR, also known as TNFRSF18(CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway. |
| Cross-reactivity | No cross-reactivity with other antigens or proteins. |
| Predicted N Terminus | Met |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 17.79 kDa |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles. |
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