Human PD-L2 Protein, His Tag
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产品编号
KMP2547
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别名
程序性死亡配体2, Human PD-L2 Protein, His Tag, PD-L2
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规格
- 50ug
- 100ug
- 200ug
产品介绍
| Alias | 程序性死亡配体2, Human PD-L2 Protein, His Tag, PD-L2 |
| Catalog Number | KMP2547 |
| Product Description | The Human PD-L2 Protein(KMP2547) is produced in HEK293 Cells. The target gene encoding the extracellular domain (Met1-Pro219) of human PD-L2 (NP_079515.2) is expressed with a C-terminal polyhistidine tag. The purified protein is biotinylated in vitro. |
| Molecular Name | PD-L2 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | Programmed death ligand 2 (PD-L2), also referred to as B7-DC and CD273, is a member of the B7 family of proteins including B7-1, B7-2, B7-H2, B7-H1 (PD-L1), and B7-H3. PD-L2 is a type I membrane protein and structurally consists of an extracellular region containing one V-like and one C-like Ig domain, a transmembrane region, and a short cytoplasmic domain. PD-L2 is expressed on antigen presenting cells, placental endothelium and medullary thymic epithelial cells, and can be induced by LPS in B cells, INF-γ in monocytes, or LPS plus IFN-γ in dendritic cells. The CD28 and B7 protein families are critical regulators of immune responses. PD-L2 and PD-L1 are two ligands for PD-1, member of the CD28/CTLA4 family expressed on activated lymphoid cells, and thus provide signals for regulating T cell activation and immune tolerance. The interaction of B7-DC/PD-1 exhibited a 2-6-fold higher affinity compared with the interaction of B7-H1/PD-1. |
| Cross-reactivity | No cross-reactivity with other antigens or proteins. |
| Predicted N Terminus | Met |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 24 kDa |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles. |
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