Human CD137 Protein, His Tag
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产品编号
KMP2462
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别名
肿瘤坏死因子超家族成员9, Human CD137 Protein, His Tag, CD137
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规格
- 50ug
- 100ug
- 200ug
产品介绍
| Alias | 肿瘤坏死因子超家族成员9, Human CD137 Protein, His Tag, CD137 |
| Catalog Number | KMP2462 |
| Product Description | The Human CD137 Protein(KMP2462) is produced in HEK293 Cells. The target gene encoding the TNFRSF9 (NP_001552.2) (Met1-Gln186) is expressed with a polyhistidine tag at the C-terminus. The purified protein is biotinylated in vitro. |
| Molecular Name | CD137 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS |
| Background | CD137 (also known as 4-1BB) is a surface co-stimulatory glycoprotein originally described as present on activated T lymphocytes, which belongs to the tumor necrosis factor (TNF) receptor superfamily. It is expressed mainly on activated CD4+ and CD8+ T cells, and binds to a high-affinity ligand (4-1BBL) expressed on several antigen-presenting cells such as macrophages and activated B cells. Upon ligand binding, 4-1BB is associated with the tumor necrosis factor receptor–associated factors (TRAFs), the adaptor protein which mediates downstream signaling events including the activation of NF-kappaB and cytokine production. 4-1BB signaling either by binding to 4-1BBL or by antibody ligation delivers signals for T-cell activation and growth, as well as monocyte proliferation and B-cell survival, and plays an important role in the amplification of T cell-mediated immune responses. In addition, CD137 and CD137L are expressed in different human primary tumor tissues, suggesting that they may influence the progression of tumors. Crosslinking of CD137 on activated T cells has shown promise in enhancing anti-tumor immune responses in murine models, and agonistic anti-CD137 antibodies are currently being tested in phase I clinical trials. Soluble forms of CD137 (sCD137) are generated by differential splicing. sCD137 can bind to CD137 ligand to antagonize the costimulatory activities of the membrane-bound CD137 and reduce T cell proliferation and IL-2 secretion. |
| Cross-reactivity | No cross-reactivity with other antigens or proteins. |
| Predicted N Terminus | Met |
| Reconstitution | Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Remarks | 收到产品后请立即按保存条件储存；使用前短暂离心，使内容物集中于管底；避免反复冻融。 |
| Shipping Condition | In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice. |
| Molecular Weight | 18.7 kDa |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles. |
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