Cynomolgus VSTM3 Protein, His Tag
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产品编号
KMP2422
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别名
具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体, T-cell immunoreceptor with Ig and ITIM domains,, VSIG9
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规格
- 50ug
- 100ug
- 200ug
产品介绍
| Alias | 具有免疫球蛋白和 ITIM 结构域的 T 细胞免疫受体, T-cell immunoreceptor with Ig and ITIM domains,, VSIG9 |
| Catalog Number | KMP2422 |
| Product Description | The Cynomolgus VSTM3 Protein(KMP2422) is produced in HEK293 Cells and the target gene encoding Met89-Pro209 is expressed with a 6His tag at the C-terminus. |
| Molecular Name | VSTM3 |
| Species | Cynomolgus |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | T cell immunoreceptor with Ig and ITIM domains(TIGIT), also called VSIG9 and Vstm3, is a member of the CD28 family within the Ig superfamily of proteins. TIGIT contains an immunoglobulin variable domain, a transmembrane domain and an immunoreceptor tyrosine-based inhibitory motif(ITIM), and is expressed on regulatory, memory, activated T cells and NK cells. TIGIT binds to CD155(PVR) that appear on dendritic cells(DC), macrophages and endothelium with high affinity, and CD112(PVRL2) with lower affinity, but not CD113(PVRL3). TIGIT-Fc fusion protein could interact with PVR on DC and enhance the secretion of IL-10, but inhibit the macrophage activation. Mice lacking TIGIT show increased T cell responses and susceptibility to autoimmune challenges, while knockdown of TIGIT with siRNA in human memory T cells did not affect T cell responses. |
| Cross-reactivity | No cross-reactivity with other antigens or proteins. |
| Predicted Molecular Weight | 13.97 kDa |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | G7NXM4 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles. |
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