Human CD155 Protein, His Tag
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产品编号
KMP2393
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别名
重组人脊髓灰质炎病毒受体, Poliovirus Receptor, CD155
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规格
- 50ug
- 100ug
- 200ug
产品介绍
| Alias | 重组人脊髓灰质炎病毒受体, Poliovirus Receptor, CD155 |
| Catalog Number | KMP2393 |
| Product Description | The Human CD155 Protein(KMP2393) is produced in HEK293 Cells and the target gene encoding Trp21-Asn343 is expressed with a 6His tag at the C-terminus. |
| Molecular Name | CD155 |
| Species | Human |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | 20mM PB, 150mM NaCl, pH7.4 |
| Background | Poliovirus Receptor(PVR) is a 70 kDa type I transmembrane single-span glycoprotein that belongs to the nectin-like(Necl) family and was originally identified based on its ability to mediate the cell attachment and entry of poliovirus(PV), an etiologic agent of the central nervous system disease poliomyelitis. PVR contains three Ig-like extracellular domains, a transmembrane segment, and a cytoplasmic tail. The normal cellular function of PVR maybe the involvement of intercellular adhension between epithelial cells. Alternate splicing of the PVR mRNA yields four different isoforms(α, β, γ, and δ) with identical extracellular domains. |
| Cross-reactivity | No cross-reactivity with other antigens or proteins. |
| Predicted Molecular Weight | 35.9 kDa |
| Predicted N Terminus | Met |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | Q6DKI7 |
| References | J. Exp. Med. 213:167-176 (2016) |
| Function | Cell surface receptor for NECTIN2. May act as a coinhibitory receptor that suppresses T-cell receptor-mediated signals. Following interaction with NECTIN2, inhibits T-cell proliferation. Competes with CD226 for NECTIN2-binding. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles. |
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