Cynomolgus CD274 Protein, His Tag
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产品编号
KMP2385
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别名
程序性死亡蛋白配体-1, programmed cell death 1 ligand 1, CD274
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规格
- 50ug
- 100ug
- 200ug
产品介绍
| Alias | 程序性死亡蛋白配体-1, programmed cell death 1 ligand 1, CD274 |
| Catalog Number | KMP2385 |
| Product Description | The Cynomolgus CD274 Protein(KMP2385) is produced in HEK293 Cells and the target gene encoding Phe19-Thr239 is expressed with a 6His tag at the C-terminus. |
| Molecular Name | CD274 |
| Species | Cynomolgus |
| Host | HEK293 Cells |
| Size | 50ug, 100ug, 200ug |
| Purity | >95% as determined by SDS-PAGE |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purification | Affinity purification |
| Endotoxin | <1.0 EU/ug determined by the LAL method |
| Formulation | PBS, pH7.4 |
| Background | CD274, also known as B7-H1 or programmed death ligand 1(PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. Programmed death-1 ligand-1(PD-L1, CD274, B7-H1) has been identified as the ligand for the immunoinhibitory receptor programmed death-1(PD1/PDCD1) and has been demonstrated to play a role in the regulation of immune responses and peripheral tolerance. By binding to PD1 on activated T-cells and B-cells, PD-L1 may inhibit ongoing T-cell responses by inducing apoptosis and arresting cell-cycle progression. Accordingly, it leads to growth of immunogenic tumor growth by increasing apoptosis of antigen specific T cells and may contribute to immune evasion by cancers. PD-L1 thus is regarded as promising therapeutic target for human autoimmune disease and malignant cancers. |
| Cross-reactivity | No cross-reactivity with other antigens or proteins. |
| Predicted Molecular Weight | 24.97 kDa |
| Predicted N Terminus | Phe 19 |
| Storage Condition | Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form. |
| Uniprot ID | G7PSE7 |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Temperature Range | Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles. |
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