Mouse CD47 Protein, Fc Tag

产品编号

KMP2353

别名

整联蛋白相关蛋白, Leukocyte Surface Antigen CD47, MER6

规格

50ug
100ug
200ug

DATASHEET COA

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产品介绍

Alias	整联蛋白相关蛋白, Leukocyte Surface Antigen CD47, MER6
Catalog Number	KMP2353
Product Description	The Mouse CD47 Protein(KMP2353) is produced in HEK293 Cells and the target gene encoding Gln19-Pro158 is expressed with a Fc tag at the C-terminus.
Molecular Name	CD47
Species	Mouse
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Concentration	联系销售经理获得最新批次的浓度
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	CD47, also known as Integrin-Associated Protein(IAP) and OA3, is a glycosylated atypical member of the immunoglobulin superfamily. Mouse CD47 is an integral membrane protein that consists of a extracellular domain(ECD) with a single Ig-like domain, five membrane-spanning regions with short intervening loops, and C-terminal cytoplasmic tail. CD47 has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. It plays an important role in memory formation and synaptic plasticity in the hippocampus. As a receptor for SIRPA, it binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cellcell adhesion, it enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. It may play a role in membrane transport and/or integrin dependent signal transduction. It also prevents premature elimination of red blood cells.
Cross-reactivity	No cross-reactivity with other antigens or proteins.
Predicted Molecular Weight	15.4 kDa
Predicted N Terminus	Met
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	A0A2R8W6P0
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles.