Human CD152 Protein, Fc Tag, Avi Tag

产品编号

KMP2303

别名

细胞毒T淋巴细胞相关抗原, Cytotoxic T-lymphocyte protein 4, CD152

规格

50ug
100ug
200ug

DATASHEET COA

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产品介绍

Alias	细胞毒T淋巴细胞相关抗原, Cytotoxic T-lymphocyte protein 4, CD152
Catalog Number	KMP2303
Product Description	The Human CD152 Protein(KMP2303) is produced in HEK293 Cells and the target gene encoding Lys36-Asp161 is expressed with a Fc, Avi tag at the C-terminus.
Molecular Name	CD152
Species	Human
Host	HEK293 Cells
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Concentration	联系销售经理获得最新批次的浓度
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method
Formulation	PBS, pH7.4
Background	Cytotoxic T-lymphocyte protein 4, is a single-pass type I membrane protein. It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4, together with their ligands, B7-1 and B7-2, constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin(Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.
Cross-reactivity	No cross-reactivity with other antigens or proteins.
Predicted Molecular Weight	13.5 kDa
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Shipping Condition	In general, the proteins are provided as lyophilized powder which are shipped at ambient temperature. They are shipped out in dry ice if supplied in liquid form.
Uniprot ID	P16410
References	1.Annu. Rev. Immunol. 24:65-97 (2006) 2.J. Exp. Med. 174:561-569 (1991)
Function	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles.