Recombinant Human CD80 Protein, His Tag

产品编号

KMH245

别名

B7, BB1, B7 1, B7.1, LAB7, CD28LG, CD28LG1, CD80 molecule

规格

50ug
100ug

DATASHEET COA

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产品介绍

Alias	B7, BB1, B7 1, B7.1, LAB7, CD28LG, CD28LG1, CD80 molecule
Catalog Number	KMH245
Molecular Name	CD80
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	CD molecule
Purity	≥90% as determined by SDS-PAGE
Concentration	联系销售经理获得最新批次的浓度
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS, pH7.5
Background	It is widely accepted that T cells require a signal induced by the engagement of the T cell receptor and a "costimulatory" signal(s) through distinct T cell surface molecules for optimal T cell expansion and activation. Members of the B7 superfamily of counterreceptors were identified by their ability to interact with costimulatory molecules found on the surface of T cells. Members of the B7 superfamily include B7-1 (CD8), B7-2 (CD86), B7-H1 (PD-L1), B7-H2 (B7RP-1), B7-H3 and PD-L2. B7-1 is expressed on activated B cells, activated T cells, mature dendritic cells and macrophages. T cells express two different receptors capable of binding B7-1, CD28 and CTLA-4. CTLA-4 binds to B7-1 with a 2 - 1 fold higher affinity than CD28. Engagement of CD28 by B7-1 increases T cell proliferation and IL-2 production and enhances the immune response. In contrast, engagement of CTLA-4 is involved in the down-regulation of the immune response. Rat and human B7-1 share 47% amino acid identity.
Cross-reactivity	No cross-reactivity with other antigens or proteins.
SDS-PAGE
Predicted N Terminus	Met
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	28.52 kDa
Note	仅供科研使用
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Temperature Range	Store the product under sterile conditions after opening at -80℃ for 12 months. Store the lyophilized powder at -25℃. Avoid repeated freeze-thaw cycles.