Recombinant Human HMGB1 Protein, His Tag
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产品编号
KMH1215
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别名
HMG1, HMG3, HMG 1, SBP 1, high mobility group box 1
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目录价格
联系客服获取报价RMB
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规格
- 50ug
- 100ug
产品介绍
| Alias | HMG1, HMG3, HMG 1, SBP 1, high mobility group box 1 |
| Catalog Number | KMH1215 |
| Molecular Name | HMGB1 |
| Species | Human |
| Host | Mammalian cells |
| Size | 50ug, 100ug |
| Protein Family | Other protein |
| Purity | ≥90% as determined by SDS-PAGE |
| Concentration | 联系销售经理获得最新批次的浓度 |
| Purification | Affinity Purification |
| Endotoxin | < 1.0 EU per ug of the protein as determined by the LAL method. |
| Formulation | PBS |
| Background | High-mobility group box 1 protein (HMGB1), previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 3 kDa, 215 amino acid (aa) single chain polypeptide containing three domains: two N-terminal globular, 7 aa positively charged DNA-binding domains (HMG boxes A and B), and a negatively charged 3 aa C-terminal region that contains only Asp and Glu.4, 5 Residues 27 - 43 and 178 - 184 contain a NLS. Posttranslational modifications of the molecule have been reported, with acetylation occurring on as many as 17 lysine residues. HMGB1 is expressed at high levels in almost all cells. It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins. |
| Application | WB, ELISA |
| Recommended Dilution | ELISA: 1:100-1:1000 |
| Cross-reactivity | No cross-reactivity with other antigens or proteins. |
| Predicted Molecular Weight | 23.54 kDa |
| Predicted N Terminus | Met |
| Reconstitution | Not applicable. The product is supplied as a ready-to-use liquid formulation. |
| Storage Condition | Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles. |
| Remarks | 收到产品后请立即按保存条件储存；使用前短暂离心，使内容物集中于管底；避免反复冻融。 |
| Shipping Condition | This product is shipped on ice packs or dry ice. |
| Stability | Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Molecular Weight | 23.54 kDa |
| Cross-reactivity | No cross-reactivity with other antigens or proteins. |
| Uniprot ID | P09429 |
| Note | 仅供科研使用 |
| ELISA IC50(ppb) | ≥ 1:1000 |
| Function | High-mobility group box 1 protein (HMGB1), previously known as HMG-1 or amphoterin, is a member of the high mobility group box family of non-histone chromosomal proteins. Human HMGB1 is expressed as a 3 kDa, 215 amino acid (aa) single chain polypeptide containing three domains: two N-terminal globular, 7 aa positively charged DNA-binding domains (HMG boxes A and B), and a negatively charged 3 aa C-terminal region that contains only Asp and Glu.4, 5 Residues 27 - 43 and 178 - 184 contain a NLS. Posttranslational modifications of the molecule have been reported, with acetylation occurring on as many as 17 lysine residues. HMGB1 is expressed at high levels in almost all cells. It was originally discovered as a nuclear protein that could bend DNA. Such bending stabilizes nucleosome formation and regulates the expression of select genes upon recruitment by DNA binding proteins. |
| Product Declaration | 该产品仅供科研使用，不可直接用于人体或注射。 |
| Temperature Range | -20℃ ~ -80℃ |
| Solubility | 产品为即用型液体，无需复溶。 |
| Appearance | Liquid |
| Product Full Name | Recombinant Human HMGB1 Protein |
| Preservative Solution | PBS |
| Target | HMGB1 |
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