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Recombinant Human PCSK9 Protein, His Tag

Recombinant Human PCSK9 Protein, His Tag

Recombinant Human PCSK9 Protein, His Tag

产品编号

KMH501

别名

FH3, PC9, FHCL3, NARC1, LDLCQ1, NARC 1, HCHOLA3, proprotein convertase subtilisin/kexin type 9

规格

50ug
100ug

DATASHEET COA

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产品介绍

Alias	FH3, PC9, FHCL3, NARC1, LDLCQ1, NARC 1, HCHOLA3, proprotein convertase subtilisin/kexin type 9
Catalog Number	KMH501
Molecular Name	PCSK9
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Antibody drug target protein
Purity	≥90% as determined by SDS-PAGE
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	Supplied as solution form in 50 mM Tris-HCl, pH 7.5, 150 mM NaCl./Lyophilized from 50 mM Tris-HCl, pH 7.5, 150 mM NaCl.
Background	Proprotein convertase subtilisin/kexin type 9 (PCSK9), also known as NARC1 (neural apoptosis regulated convertase), is a newly identified subtilase belonging to the peptidase S8 subfamily. Mouse PCSK9 is synthesized as a soluble zymogen, and undergoes autocatalytic intramolecular processing in the endoplasmic reticulum, resulting in the cleavage of its propeptide that remains associated with the secreted active enzyme with a broad alkaline pH optimum. This protein plays a major regulatory role in cholesterol homeostasis. PCSK9 binds to the epidermal growth factor-like repeat A (EGF-A) domain of the low-density lipoprotein receptor (LDLR), inducing LDLR degradation. PCSK9 may also have a role in the differentiation of cortical neurons.[1] Mutations in this gene have been associated with a rare form of autosomal dominant familial hypercholesterolemia (HCHOLA3).[2-3]
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Shipping Condition	This product is shipped on ice packs or dry ice.
Molecular Weight	58.17 kDa
Note	仅供科研使用

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