Recombinant Human EPCR/PROCR Protein, His Tag

产品编号

KMH1027

别名

CCCA, EPCR, CCD41, protein C receptor

目录价格

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规格

50ug
100ug

DATASHEET COA

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产品介绍

Alias	CCCA, EPCR, CCD41, protein C receptor
Catalog Number	KMH1027
Molecular Name	PROCR
Species	Human
Host	Mammalian cells
Size	50ug, 100ug
Protein Family	Other protein
Purity	≥90% as determined by SDS-PAGE
Concentration	联系销售经理获得最新批次的浓度
Purification	Affinity Purification
Endotoxin	< 1.0 EU per ug of the protein as determined by the LAL method.
Formulation	PBS
Background	Endothelial Protein C Receptor (EPCR) is a Vitamin Kdependent Serine Protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (ProteaseActivated Receptor 1) on endothelial cells and subsequent upregulation of Protein Cinduced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology. EPCR plays an important role in augmenting Protein C activation by the ThrombinThrombomodulin complex and in regulating blood coagulation and inflammation. EPCR is found primarily on endothelial cells. Deletion of EPCR function results in embryonic death, at least in part due to placental thrombosis.
Application	WB, ELISA
Recommended Dilution	ELISA: 1:100-1:1000
Cross-reactivity	No cross-reactivity with other antigens or proteins.
Predicted Molecular Weight	21.34 kDa
Predicted N Terminus	Met
Reconstitution	Not applicable. The product is supplied as a ready-to-use liquid formulation.
Storage Condition	Store the product under sterile conditions after opening at -20℃ to -80℃ for 12 months. Avoid repeated freeze-thaw cycles.
Remarks	收到产品后请立即按保存条件储存；使用前短暂离心，使内容物集中于管底；避免反复冻融。
Shipping Condition	This product is shipped on ice packs or dry ice.
Stability	Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Molecular Weight	21.34 kDa
Cross-reactivity	No cross-reactivity with other antigens or proteins.
Uniprot ID	Q9UNN8
Note	仅供科研使用
ELISA IC50(ppb)	≥ 1:1000
Function	Endothelial Protein C Receptor (EPCR) is a Vitamin Kdependent Serine Protease that plays a major role in blood coagulation. Binding of Protein C to EPCR leads to the proteolytic activation of PAR1 (ProteaseActivated Receptor 1) on endothelial cells and subsequent upregulation of Protein Cinduced genes. EPCR is a type I transmembrane glycoprotein in the CD1/MHC family. It is expressed most strongly in the endothelial cells of arteries and veins in heart and lung. Membrane bound EPCR is released by metalloproteolytic cleavage to generate the soluble receptor. The extracellular domain of human and mouse EPCR shares approximately 61% amino acid sequence homology. EPCR plays an important role in augmenting Protein C activation by the ThrombinThrombomodulin complex and in regulating blood coagulation and inflammation. EPCR is found primarily on endothelial cells. Deletion of EPCR function results in embryonic death, at least in part due to placental thrombosis.
Product Declaration	该产品仅供科研使用，不可直接用于人体或注射。
Temperature Range	-20℃ ~ -80℃
Solubility	产品为即用型液体，无需复溶。
Appearance	Liquid
Product Full Name	Recombinant Human EPCR/PROCR Protein
Preservative Solution	PBS
Usage Method	冻干粉请按“复溶”说明用无菌去离子水复溶后使用，液体产品可直接使用；具体工作浓度请参考“推荐稀释比例”。
Target	PROCR