Rabbit Anti-Human BRAF pAb
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产品编号
PA4220
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别名
BRAF, B-RAF1, B-raf, BRAF1, NS7, RAFB1
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规格
- 50ul
- 100ul
Alias | BRAF, B-RAF1, B-raf, BRAF1, NS7, RAFB1 |
Catalog Number | PA4220 |
Molecular Name | BRAF |
Host | Rabbit |
Size | 50ul, 100ul |
Clonity | Polyclonal |
Purification | Affinity Purification |
Formulation | Supply in PBS with 0.02% sodium azide, 50% glycerol, pH 7.4. |
Immunogen | Recombinant fusion protein containing a sequence corresponding to a.a. 280-460 of human BRAF (NP_004324.2). |
Application | WB, IHC |
Storage Condition | Store the product under sterile conditions after opening at -20℃. Avoid freeze-thaw cycles. |
Shipping Condition | Shipped on ice packs. |
Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
Product Full Name | Rabbit Anti-Human BRAF Polyclonal Antibody |
BRAF是MAPK信号通路中的丝氨酸/苏氨酸激酶,调控细胞增殖、分化及凋亡。BRAF V600E突变导致组成性激活,与黑色素瘤、结直肠癌及甲状腺癌密切相关。
可以,推荐使用BRAF V600E突变细胞系(如A375),通过WB检测BRAF抑制剂(如Vemurafenib)对ERK磷酸化的抑制作用。
经测试无交叉反应,特异性针对BRAF。