Rabbit ABCC1 PAb_天津卡梅德科技发展有限公司

>>

>>

>>

>

Rabbit ABCC1 PAb

Rabbit ABCC1 PAb

产品编号

PA17210

别名

multidrug resistance-associated protein 1

规格

50ul
100ul

DATASHEET MSDS

立即询价加入询价列表大包装定制

产品介绍

Alias	multidrug resistance-associated protein 1
Catalog Number	PA17210
Molecular Name	ABCC1
Host	Rabbit
Size	50ul, 100ul
Clonity	Polyclonal
Purification	Affinity purification
Formulation	PBS, 0.02% sodium azide, 50% glycerol, pH7.3
Background	The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
Immunogen	This antibody is immunized by recombinant fusion protein containing a sequence corresponding to amino acids 850-960 of human ABCC1 (NP_004987.2).
Storage Condition	This product can be stored at 2℃-8℃ for one month. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.
Shipping Condition	Shipped on ice packs.
Cross-reactivity	Human, Rat
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。

FAQ

Q1- ABCC1（MRP1）蛋白的生物学功能是什么？

ABCC1属于ABC转运蛋白家族，介导谷胱甘肽结合物和外源毒素的跨膜外排，与肿瘤多药耐药性（MDR）相关。
Q2- 该抗体是否适用于检测癌细胞的多药耐药表型？

是的，适用于耐药细胞系（如MCF7/ADR）的WB和IF检测，建议结合化疗药物（如阿霉素）处理验证功能。
Q3- 如何验证抗体特异性？

提供ABCC1过表达细胞与空载体对照的WB数据，预期条带约190 kDa。
Q4- 是否适用于膜蛋白的流式细胞术检测？

需使用非透化条件（仅表面染色），抗体推荐稀释比例1:50-1:100。
Q5- 抗体保存条件及有效期？

-20℃分装保存（避免冻融），有效期2年；短期使用可4℃保存1个月。

推荐产品

400-621-6806
614353794
周一至周五 9:00-18:00
0