Rabbit Anti-ABCAC/ABCA12 Polyclonal Antibody
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产品编号
PAV254
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别名
ATP binding cassette subfamily A member 12, LI2, ICR2B, ARCI4A, ARCI4B
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规格
- 100ul
产品介绍
| Alias | ATP binding cassette subfamily A member 12, LI2, ICR2B, ARCI4A, ARCI4B |
| Catalog Number | PAV254 |
| Molecular Name | ABCA12 |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Immunogen | This antibody was raised against from human ABCA12 protein at amino acid: 2170-2250 |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-300 |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
FAQ
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Q1- ABCAC/ABCA12蛋白的功能是什么是什么？
ABCAC/ABCA12参与脂质转运和皮肤屏障功能，其突变导致板层状鱼鳞病（LI），表现为皮肤干燥和过度角化。
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Q2- 是否适用于皮肤组织的IHC检测？
是的，推荐石蜡切片，需蛋白酶K修复（10 μg/mL，37℃ 15分钟），抗体稀释1:200。
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Q3- 抗体是否识别小鼠Abcac/Abca12蛋白？
与人同源性约75%，可部分检测，需预实验优化浓度（推荐1:800）。
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Q4- Western Blot中预期条带大小是多少？
理论分子量约300 kDa，实际可能因糖基化显示为310-320 kDa。
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Q5- 是否提供LI患者样本的阴性对照？
是的，提供患者皮肤组织IHC显示ABCA12表达缺失的验证结果。
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