Inactivated Pneumococcal Type III Antigen
-
产品编号
BAG1109
-
别名
灭活3型肺炎球菌抗原,灭活肺炎球菌抗原, 肺炎球菌, Inactivated Pneumococcal Type III, Pneumococcal
-
规格
- 250ul
- 1ml
| Catalog Number | BAG1109 |
| Alias | 灭活3型肺炎球菌抗原,灭活肺炎球菌抗原, 肺炎球菌, Inactivated Pneumococcal Type III, Pneumococcal |
| Size | 250ul, 1ml |
| Molecular Name | Pneumococcal |
| Expression System | Pneumococcal |
| Species | Bacteria |
| Purity | >95% |
| Purification | IEC & HPLC |
| Storage Condition | Store the lyophilized powder at 4℃ for 6 months. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Formulation | Powder or 0.1M PBS, PH 7.0 |
| Background | In most cases, once pneumococcal pneumonia has been identified, doctors will prescribe antibiotics. These antibiotic usually help alleviate and eliminate symptoms between 12 and 36 hours after being taken. Despite most antibiotics' effectiveness in treating the disease, sometimes the bacteria can resist the antibiotics, causing symptoms to worsen. Additionally, age and health of the infected patient can contribute to the effectiveness of the antibiotics. |
| Application | Immunogen, WB, ELISA |
CRM197 是一种无毒的白喉毒素突变体蛋白。它本身没有毒性,但保留了极强的免疫原性。在肺炎球菌结合疫苗中,它的角色是 “蛋白质载体” 。 核心作用: 肺炎球菌的荚膜多糖(针对不同血清型,如4型、6B型、19F型等)属于T细胞非依赖性抗原。单独接种时,它们在婴幼儿体内只能引起较弱的免疫反应,且不能产生免疫记忆。通过化学方法将这些多糖共价结合到CRM197载体蛋白上,就将疫苗变成了 “T细胞依赖性抗原” 。这使得婴幼儿的免疫系统能够被有效激活,产生更强、更持久的保护性抗体,并形成免疫记忆。
0