Cutibacterium Acnes CAMP Factor Protein, His Tag_天津卡梅德科技发展有限公司

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Cutibacterium Acnes CAMP Factor Protein, His Tag

Cutibacterium Acnes CAMP Factor Protein, His Tag

产品编号

KMP4410

别名

规格

50ug
100ug
200ug

DATASHEET MSDS

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产品介绍

Catalog Number	KMP4410
Molecular Name	CAMP Factor
Size	50ug, 100ug, 200ug
Purity	>95% as determined by SDS-PAGE
Product Description	The Cutibacterium Acnes CAMP Factor Protein, His Tag(KMP4410) is produced in Insect Cells. A DNA sequence encoding the Cutibacterium acnes CAMP factor (EPI1629568) (Met1-Tyr560) was expressed with a polyhistidine tag at the C-terminus.
Storage Condition	Aliquot and store at -20℃ to -80℃. Avoid repeated freezing and thawing cycles.
Formulation	20mM Tris, 300mM NaCl, 10% Glycerol, pH8.0
Shipping Condition	In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. If supplied as liquid, the proteins will be shipped with dry ice.
Background	CAMP factor is an extracellular cytolytic protein produced by Streptococcus agalactiae. CAMP factor binds the Fc fragments of IgG and is also known as protein B, in analogy to protein A of Staphylococcus aureus.
Species	Cutibacterium Acnes
Host	Insect Cells
Purification	Affinity purification
Endotoxin	<1.0 EU/ug determined by the LAL method

FAQ

Q1-CAMP因子的致病机制是什么？

CAMP因子通过协同溶血作用破坏宿主细胞膜，促进痤疮丙酸杆菌的炎症反应和皮肤定植。
Q2-His标签的位置是否影响蛋白功能？

His标签位于C端，经溶血活性实验验证不影响其与协同溶血素（如金黄色葡萄球菌β-毒素）的相互作用。
Q3-该蛋白可用于哪些研究模型？

适用于痤疮发病机制研究、抗菌药物筛选或皮肤免疫微环境体外模拟实验。
Q4-纯化过程中是否去除内毒素？

经Ni柱纯化后，额外通过去内毒素柱处理，内毒素水平<0.1 EU/μg。
Q5-蛋白的活性检测方法是什么？

使用绵羊红细胞与β-毒素共孵育法，通过溶血圈直径定量CAMP因子活性。

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