Rabbit Anti-S12A1/SLC12A1 Polyclonal Antibody
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产品编号
PAV3514
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别名
solute carrier family 12 member 1, BSC, BSC-1, BSC1, CCC2, NKCC2
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | solute carrier family 12 member 1, BSC, BSC-1, BSC1, CCC2, NKCC2 |
| Catalog Number | PAV3514 |
| Product Description | Rabbit polyclonal antibody raised against human SLC12A1 (Solute carrier family 12 member 1-chloride cotransporter 1)). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SLC12A1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转运蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010] |
| Immunogen | This antibody was raised against from part region of human SLC12A1 protein (UniProt: Q13621) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 6557 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈121.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 121.5 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q13621 |
| Note | Gene ID: 6557; UniProt: Q13621; Chromosome: 15q21.1; Predicted MW: 121.5 kDa |
| Function | Renal sodium, potassium and chloride non-electrogenic ion symporter that mediates the transepithelial NaCl reabsorption in the thick ascending limb and plays an essential role in the urinary concentration and volume regulation. It can substitute NH4(+) for K(+), enabling NH4(+) apical transmembrane transport in the medullary thick ascending limb (MTAL). This function is crucial for maintaining ammonium homeostasis by the kidney, particularly during metabolic acidosis (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SLC12A1 Polyclonal Antibody |
| Target | SLC12A1 |
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