Rabbit Anti-NRAM2/SLC11A2 Polyclonal Antibody
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产品编号
PAV2599
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别名
solute carrier family 11 member 2, AHMIO1, DCT1, DMT1, NRAMP2
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | solute carrier family 11 member 2, AHMIO1, DCT1, DMT1, NRAMP2 |
| Catalog Number | PAV2599 |
| Product Description | Rabbit polyclonal antibody raised against human SLC11A2 (Natural resistance-associated macrophage protein 2). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SLC11A2 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转运蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010] |
| Immunogen | This antibody was raised against from part region of human SLC11A2 protein (UniProt: P49281) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 4891 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈62.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 62.3 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | P49281 |
| Note | Gene ID: 4891; UniProt: P49281; Chromosome: 12q13.12; Predicted MW: 62.3 kDa |
| Function | Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1. Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity). Can mediate uncoupled fluxes of either protons or metal ions. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SLC11A2 Polyclonal Antibody |
| Target | SLC11A2 |
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