Rabbit Anti-NLTP/SCP2 Polyclonal Antibody
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产品编号
PAV2545
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别名
sterol carrier protein 2, NLTP, NSL-TP, SCOX, SCP-2, SCP-CHI, SCP-X, SCPX, nsLTP
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | sterol carrier protein 2, NLTP, NSL-TP, SCOX, SCP-2, SCP-CHI, SCP-X, SCPX, nsLTP |
| Catalog Number | PAV2545 |
| Product Description | Rabbit polyclonal antibody raised against human SCP2 (Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SCP2 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转运蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes two proteins: sterol carrier protein X (SCPx) and sterol carrier protein 2 (SCP2), as a result of transcription initiation from 2 independently regulated promoters. The transcript initiated from the proximal promoter encodes the longer SCPx protein, and the transcript initiated from the distal promoter encodes the shorter SCP2 protein, with the 2 proteins sharing a common C-terminus. Evidence suggests that the SCPx protein is a peroxisome-associated thiolase that is involved in the oxidation of branched chain fatty acids, while the SCP2 protein is thought to be an intracellular lipid transfer protein. This gene is highly expressed in organs involved in lipid metabolism, and may play a role in Zellweger syndrome, in which cells are deficient in peroxisomes and have impaired bile acid synthesis. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[provided by RefSeq, Aug 2010] |
| Immunogen | This antibody was raised against from part region of human SCP2 protein (UniProt: O14595) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 6342 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈30.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 30.7 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | O14595 |
| Note | Gene ID: 6342; UniProt: O14595; Chromosome: 1p32.3; Predicted MW: 30.7 kDa |
| Function | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SCP2 Polyclonal Antibody |
| Target | SCP2 |
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