Rabbit Anti-MRP/ABCC1 Polyclonal Antibody
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产品编号
PAV2365
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别名
ATP binding cassette subfamily C member 1 (ABCC1 blood group), ABC29, ABCC, DFNA77, GS-X, MRP, MRP1
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | ATP binding cassette subfamily C member 1 (ABCC1 blood group), ABC29, ABCC, DFNA77, GS-X, MRP, MRP1 |
| Catalog Number | PAV2365 |
| Product Description | Rabbit polyclonal antibody raised against human ABCC1 (ATP-binding cassette sub-family C member 1 transporter)). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | ABCC1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转运蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012] |
| Immunogen | This antibody was raised against from part region of human ABCC1 protein (UniProt: P33527) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 4363 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈171.6 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 171.6 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | P33527 |
| Note | Gene ID: 4363; UniProt: P33527; Chromosome: 16p13.11; Predicted MW: 171.6 kDa |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable the active transport of organic anions conjugated with glutathione, glucuronate or sulfate. Operates at the plasma membrane where it mediates the efflux of substrates from the cytoplasm into the extracellular space. The rate of transport is in some way coupled to the reduced glutathione (GSH) intracellular levels. Mediates the systemic release of glutathione-conjugated leukotriene C4 (LTC4) from myeloid cells such as mast cells, as part of the inflammatory response. Exports S-geranylgeranyl-glutathione (GGG) in lymphoid cells and stromal compartments of lymphoid organs. ABCC1 (via extracellular transport) with GGT5 (via GGG catabolism) establish GGG gradients within lymphoid tissues to position P2RY8-positive lymphocytes at germinal centers in lymphoid follicles and restrict their chemotactic transmigration from blood vessels to the bone marrow parenchyma (By similarity). Mediates basolateral export of GSH-conjugated R- and S-prostaglandin A2 diastereomers in polarized epithelial cells. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human ABCC1 Polyclonal Antibody |
| Target | ABCC1 |
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