Rabbit Anti-SYAC/AARS1 Polyclonal Antibody
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产品编号
PAV3885
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别名
alanyl-tRNA synthetase 1, AARS, CMT2N, DEE29, EIEE29, HDLS2, TTD8
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | alanyl-tRNA synthetase 1, AARS, CMT2N, DEE29, EIEE29, HDLS2, TTD8 |
| Catalog Number | PAV3885 |
| Product Description | Rabbit polyclonal antibody raised against human AARS1 (Alanine--tRNA ligase, cytoplasmic). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | AARS1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 翻译与核糖体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human AARS1 protein (UniProt: P49588) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 16 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈106.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 106.8 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | P49588 |
| Note | Gene ID: 16; UniProt: P49588; Chromosome: 16q22.1; Predicted MW: 106.8 kDa |
| Function | Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. In presence of high levels of lactate, also acts as a protein lactyltransferase that mediates lactylation of lysine residues in target proteins, such as TEAD1, TP53/p53 and YAP1. Protein lactylation takes place in a two-step reaction: lactate is first activated by ATP to form lactate-AMP and then transferred to lysine residues of target proteins. Acts as an inhibitor of TP53/p53 activity by catalyzing lactylation of TP53/p53. Acts as a positive regulator of the Hippo pathway by mediating lactylation of TEAD1 and YAP1. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human AARS1 Polyclonal Antibody |
| Target | AARS1 |
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