Rabbit Anti-SLN12/SLFN12 Polyclonal Antibody
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产品编号
PAV3710
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别名
schlafen family member 12, SLFN3
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | schlafen family member 12, SLFN3 |
| Catalog Number | PAV3710 |
| Product Description | Rabbit polyclonal antibody raised against human SLFN12 (Ribonuclease SLFN12). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SLFN12 |
| Species | Human |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 翻译与核糖体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables RNA nuclease activity and ribosome binding activity. Involved in apoptotic signaling pathway and rRNA catabolic process. Part of cytosol and nucleus. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human SLFN12 protein (UniProt: Q8IYM2) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 55106 |
| Tag | Unconjugated |
| Cross-reactivity | Human |
| Predicted Molecular Weight | ≈67.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 67.0 kDa |
| Cross-reactivity | Human |
| Uniprot ID | Q8IYM2 |
| Note | Gene ID: 55106; UniProt: Q8IYM2; Chromosome: 17q12; Predicted MW: 67.0 kDa |
| Function | Ribonuclease which is part of an E2/17beta-estradiol-induced pro-apoptotic signaling pathway. E2 stabilizes the PDE3A/SLFN12 complex in the cytosol, promoting the dephosphorylation of SLFN12 and activating its pro-apoptotic ribosomal RNA/rRNA ribonuclease activity. This apoptotic pathway might be relevant in tissues with high concentration of E2 and be for instance involved in placenta remodeling. May play a role in cell differentiation. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SLFN12 Polyclonal Antibody |
| Target | SLFN12 |
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