Rabbit Anti-S61A1/SEC61A1 Polyclonal Antibody
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产品编号
PAV3555
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别名
SEC61 translocon subunit alpha 1, ADTKD5, CVID15, HNFJ4, HSEC61, SEC61, SEC61A
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | SEC61 translocon subunit alpha 1, ADTKD5, CVID15, HNFJ4, HSEC61, SEC61, SEC61A |
| Catalog Number | PAV3555 |
| Product Description | Rabbit polyclonal antibody raised against human SEC61A1 (Protein transport protein Sec61 subunit alpha isoform 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SEC61A1 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 翻译与核糖体 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene belongs to the SECY/SEC61- alpha family. It appears to play a crucial role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. This protein found to be tightly associated with membrane-bound ribosomes, either directly or through adaptor proteins. This gene encodes an alpha subunit of the heteromeric SEC61 complex, which also contains beta and gamma subunits. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human SEC61A1 protein (UniProt: P61619) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 29927 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈52.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 52.3 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | P61619 |
| Note | Gene ID: 29927; UniProt: P61619; Chromosome: 3q21.3; Predicted MW: 52.3 kDa |
| Function | Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across the endoplasmic reticulum (ER). Forms a ribosome receptor and a gated pore in the ER membrane, both functions required for cotranslational translocation of nascent polypeptides. May cooperate with auxiliary protein SEC62, SEC63 and HSPA5/BiP to enable post-translational transport of small presecretory proteins. The SEC61 channel is also involved in ER membrane insertion of transmembrane proteins: it mediates membrane insertion of the first few transmembrane segments of proteins, while insertion of subsequent transmembrane regions of multi-pass membrane proteins is mediated by the multi-pass translocon (MPT) complex. The SEC61 channel cooperates with the translocating protein TRAM1 to import nascent proteins into the ER. Controls the passive efflux of calcium ions from the ER lumen to the cytosol through SEC61 channel, contributing to the maintenance of cellular calcium homeostasis. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SEC61A1 Polyclonal Antibody |
| Target | SEC61A1 |
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