Rabbit Anti-TLE3 Polyclonal Antibody
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产品编号
PAV4041
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别名
TLE family member 3, transcriptional corepressor, ESG, ESG3, GRG3, HsT18976
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | TLE family member 3, transcriptional corepressor, ESG, ESG3, GRG3, HsT18976 |
| Catalog Number | PAV4041 |
| Product Description | Rabbit polyclonal antibody raised against human TLE3 (Transducin-like enhancer protein 3). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TLE3 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录因子 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013] |
| Immunogen | This antibody was raised against from part region of human TLE3 protein (UniProt: Q04726) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 7090 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈83.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 83.4 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q04726 |
| Note | Gene ID: 7090; UniProt: Q04726; Chromosome: 15q23; Predicted MW: 83.4 kDa |
| Function | Transcriptional coregulator that binds to a number of transcription factors. Acts as a regulator of adipogenesis both by acting as a corepressor of Wnt signaling and coactivator for PPARG. Inhibits the transcriptional activation mediated by CTNNB1 and TCF family members in Wnt signaling. Promotes diffentiation of white adipocytes by acting as a coactivator for PPARG and preventing the association between PRDM16 and PPARG, thereby preventing browning of white adipocytes (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TLE3 Polyclonal Antibody |
| Target | TLE3 |
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