Rabbit Anti-TF2H4/GTF2H4 Polyclonal Antibody
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产品编号
PAV4002
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别名
general transcription factor IIH subunit 4, P52, TFB2, TFIIH, XPJ
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | general transcription factor IIH subunit 4, P52, TFB2, TFIIH, XPJ |
| Catalog Number | PAV4002 |
| Product Description | Rabbit polyclonal antibody raised against human GTF2H4 (General transcription factor IIH subunit 4). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | GTF2H4 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录因子 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in nuclear speck. Part of core TFIIH complex portion of holo TFIIH complex and transcription factor TFIID complex. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human GTF2H4 protein (UniProt: Q92759) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 2968 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈52.2 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 52.2 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q92759 |
| Note | Gene ID: 2968; UniProt: Q92759; Chromosome: 6p21.33; Predicted MW: 52.2 kDa |
| Function | Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.; FUNCTION: Stimulates the ATPase activity of TFIIH subunit XPB/ERCC3. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human GTF2H4 Polyclonal Antibody |
| Target | GTF2H4 |
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