Rabbit Anti-SOX5 Polyclonal Antibody

产品编号

PAV3760

别名

SRY-box transcription factor 5, L-SOX5, L-SOX5B, L-SOX5F, LAMSHF

目录价格

InquiryRMB

规格

100ul

DATASHEET COA

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产品介绍

Alias	SRY-box transcription factor 5, L-SOX5, L-SOX5B, L-SOX5F, LAMSHF
Catalog Number	PAV3760
Product Description	Rabbit polyclonal antibody raised against human SOX5 (Transcription factor SOX-5). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	SOX5
Species	Human, Mouse
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	转录因子
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Immunogen	This antibody was raised against from part region of human SOX5 protein (UniProt: P35711)
Application	WB
Recommended Dilution	WB 1:500-2000
Gene ID	6660
Tag	Unconjugated
Cross-reactivity	Human, Mouse
Predicted Molecular Weight	≈84.0 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	84.0 kDa
Cross-reactivity	Human, Mouse
Uniprot ID	P35711
Note	Gene ID: 6660; UniProt: P35711; Chromosome: 12p12.1; Predicted MW: 84.0 kDa
Function	Transcription factor involved in chondrocytes differentiation and cartilage formation. Specifically binds the 5'-AACAAT-3' DNA motif present in enhancers and super-enhancers and promotes expression of genes important for chondrogenesis, including cartilage matrix protein-coding genes, such as COL2A1 and AGC1. Required for overt chondrogenesis when condensed prechondrocytes differentiate into early stage chondrocytes: SOX5 and SOX6 cooperatively bind with SOX9 on active enhancers and super-enhancers associated with cartilage-specific genes, and thereby potentiate SOX9's ability to transactivate. Not involved in precartilaginous condensation, the first step in chondrogenesis, during which skeletal progenitors differentiate into prechondrocytes. Together with SOX6, required to form and maintain a pool of highly proliferating chondroblasts between epiphyses and metaphyses, to form columnar chondroblasts, delay chondrocyte prehypertrophy but promote hypertrophy, and to delay terminal differentiation of chondrocytes on contact with ossification fronts.
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human SOX5 Polyclonal Antibody
Target	SOX5