Rabbit Anti-PITX3 Polyclonal Antibody

产品编号

PAV3048

别名

paired like homeodomain 3, ASGD1, ASMD, ASOD, CTPP4, CTRCT11

目录价格

InquiryRMB

规格

100ul

DATASHEET COA

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产品介绍

Alias	paired like homeodomain 3, ASGD1, ASMD, ASOD, CTPP4, CTRCT11
Catalog Number	PAV3048
Product Description	Rabbit polyclonal antibody raised against human PITX3 (Pituitary homeobox 3). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	PITX3
Species	Human, Mouse, Rat
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	转录因子
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts. [provided by RefSeq, Jul 2008]
Immunogen	This antibody was raised against from part region of human PITX3 protein (UniProt: O75364)
Application	WB, ELISA
Recommended Dilution	WB 1:500-2000 ELISA 1:5000-20000
Gene ID	5309
Tag	Unconjugated
Cross-reactivity	Human, Mouse, Rat
Predicted Molecular Weight	≈31.8 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	31.8 kDa
Cross-reactivity	Human, Mouse, Rat
Uniprot ID	O75364
Note	Gene ID: 5309; UniProt: O75364; Chromosome: 10q24.32; Predicted MW: 31.8 kDa
Function	Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. In addition to its importance during development, it also has roles in the long-term survival and maintenance of the mdDA neurons. Activates NR4A2/NURR1-mediated transcription of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons. Acts by decreasing the interaction of NR4A2/NURR1 with the corepressor NCOR2/SMRT which acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state. Essential for the normal lens development and differentiation. Plays a critical role in the maintenance of mitotic activity of lens epithelial cells, fiber cell differentiation and in the control of the temporal and spatial activation of fiber cell-specific crystallins.
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human PITX3 Polyclonal Antibody
Target	PITX3