Rabbit Anti-NF2L1/NFE2L1 Polyclonal Antibody
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产品编号
PAV2509
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别名
NFE2 like bZIP transcription factor 1, LCR-F1, NRF-1, NRF1, TCF11
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | NFE2 like bZIP transcription factor 1, LCR-F1, NRF-1, NRF1, TCF11 |
| Catalog Number | PAV2509 |
| Product Description | Rabbit polyclonal antibody raised against human NFE2L1 (Endoplasmic reticulum membrane sensor NFE2L1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | NFE2L1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录因子 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for "nuclear respiratory factor 1" which has an official symbol of NRF1. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human NFE2L1 protein (UniProt: Q14494) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 4779 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈84.7 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 84.7 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q14494 |
| Note | Gene ID: 4779; UniProt: Q14494; Chromosome: 17q21.32; Predicted MW: 84.7 kDa |
| Function | [Endoplasmic reticulum membrane sensor NFE2L1]: Endoplasmic reticulum membrane sensor that translocates into the nucleus in response to various stresses to act as a transcription factor. Constitutes a precursor of the transcription factor NRF1 (By similarity). Able to detect various cellular stresses, such as cholesterol excess, oxidative stress or proteasome inhibition. In response to stress, it is released from the endoplasmic reticulum membrane following cleavage by the protease DDI2 and translocates into the nucleus to form the transcription factor NRF1 (By similarity). Acts as a key sensor of cholesterol excess: in excess cholesterol conditions, the endoplasmic reticulum membrane form of the protein directly binds cholesterol via its CRAC motif, preventing cleavage and release of the transcription factor NRF1, thereby allowing expression of genes promoting cholesterol removal, such as CD36 (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human NFE2L1 Polyclonal Antibody |
| Target | NFE2L1 |
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