Rabbit Anti-MCR/NR3C2 Polyclonal Antibody
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产品编号
PAV2270
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别名
nuclear receptor subfamily 3 group C member 2, MCR, MLR, MR, NR3C2VIT
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | nuclear receptor subfamily 3 group C member 2, MCR, MLR, MR, NR3C2VIT |
| Catalog Number | PAV2270 |
| Product Description | Rabbit polyclonal antibody raised against human NR3C2 (Mineralocorticoid receptor). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | NR3C2 |
| Species | Human, Rat, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录因子 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| Immunogen | This antibody was raised against from part region of human NR3C2 protein (UniProt: P08235) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 4306 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat, Mouse |
| Predicted Molecular Weight | ≈107.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 107.1 kDa |
| Cross-reactivity | Human, Rat, Mouse |
| Uniprot ID | P08235 |
| Note | Gene ID: 4306; UniProt: P08235; Chromosome: 4q31.23; Predicted MW: 107.1 kDa |
| Function | Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human NR3C2 Polyclonal Antibody |
| Target | NR3C2 |
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