Rabbit Anti-SPT6H/SUPT6H Polyclonal Antibody
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产品编号
PAV3803
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别名
SPT6 homolog, histone chaperone and transcription elongation factor, SPT6, SPT6H, emb-5
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | SPT6 homolog, histone chaperone and transcription elongation factor, SPT6, SPT6H, emb-5 |
| Catalog Number | PAV3803 |
| Product Description | Rabbit polyclonal antibody raised against human SUPT6H (Transcription elongation factor SPT6). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SUPT6H |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录与RNA加工 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables histone binding activity. Involved in transcription elongation-coupled chromatin remodeling. Predicted to be located in nucleoplasm. Predicted to be part of transcription elongation factor complex. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human SUPT6H protein (UniProt: Q7KZ85) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 6830 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈199.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 199.1 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q7KZ85 |
| Note | Gene ID: 6830; UniProt: Q7KZ85; Chromosome: 17q11.2; Predicted MW: 199.1 kDa |
| Function | Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SUPT6H Polyclonal Antibody |
| Target | SUPT6H |
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