Rabbit Anti-RTF1 Polyclonal Antibody
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产品编号
PAV3498
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别名
RTF1 homolog, Paf1/RNA polymerase II complex component, GTL7, KIAA0252
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | RTF1 homolog, Paf1/RNA polymerase II complex component, GTL7, KIAA0252 |
| Catalog Number | PAV3498 |
| Product Description | Rabbit polyclonal antibody raised against human RTF1 (RNA polymerase-associated protein RTF1 homolog). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RTF1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录与RNA加工 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA. [provided by RefSeq, Sep 2010] |
| Immunogen | This antibody was raised against from part region of human RTF1 protein (UniProt: Q92541) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 23168 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈80.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 80.3 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q92541 |
| Note | Gene ID: 23168; UniProt: Q92541; Chromosome: 15q15.1; Predicted MW: 80.3 kDa |
| Function | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non-phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both independently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RTF1 Polyclonal Antibody |
| Target | RTF1 |
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