Rabbit Anti-RRP44/DIS3 Polyclonal Antibody
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产品编号
PAV3472
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别名
DIS3 exosome endoribonuclease and 3'-5' exoribonuclease, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | DIS3 exosome endoribonuclease and 3'-5' exoribonuclease, 2810028N01Rik, EXOSC11, KIAA1008, RRP44, dis3p |
| Catalog Number | PAV3472 |
| Product Description | Rabbit polyclonal antibody raised against human DIS3 (Exosome complex exonuclease RRP44). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | DIS3 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录与RNA加工 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables 3'-5'-RNA exonuclease activity; endonuclease activity; and guanyl-nucleotide exchange factor activity. Involved in CUT catabolic process; RNA processing; and rRNA catabolic process. Located in cytosol and nucleoplasm. Part of nuclear exosome (RNase complex). Implicated in primary ovarian insufficiency. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human DIS3 protein (UniProt: Q9Y2L1) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 22894 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈109.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 109.0 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9Y2L1 |
| Note | Gene ID: 22894; UniProt: Q9Y2L1; Chromosome: 13q21.33; Predicted MW: 109.0 kDa |
| Function | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human DIS3 Polyclonal Antibody |
| Target | DIS3 |
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