Rabbit Anti-RPR1B/RPRD1B Polyclonal Antibody
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产品编号
PAV3463
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别名
regulation of nuclear pre-mRNA domain containing 1B, C20orf77, CREPT, K-H, Kub5-Hera, NET60, dJ1057B20.2
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | regulation of nuclear pre-mRNA domain containing 1B, C20orf77, CREPT, K-H, Kub5-Hera, NET60, dJ1057B20.2 |
| Catalog Number | PAV3463 |
| Product Description | Rabbit polyclonal antibody raised against human RPRD1B (Regulation of nuclear pre-mRNA domain-containing protein 1B). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RPRD1B |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录与RNA加工 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables RNA polymerase II complex binding activity and identical protein binding activity. Involved in several processes, including RNA polymerase II promoter clearance; positive regulation of cell population proliferation; and positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription preinitiation complex. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human RPRD1B protein (UniProt: Q9NQG5) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 58490 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈36.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 36.9 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9NQG5 |
| Note | Gene ID: 58490; UniProt: Q9NQG5; Chromosome: 20q11.23; Predicted MW: 36.9 kDa |
| Function | Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD by RPAP2. Transcriptional regulator which enhances expression of CCND1. Promotes binding of RNA polymerase II to the CCDN1 promoter and to the termination region before the poly-A site but decreases its binding after the poly-A site. Prevents RNA polymerase II from reading through the 3' end termination site and may allow it to be recruited back to the promoter through promotion of the formation of a chromatin loop. Also enhances the transcription of a number of other cell cycle-related genes including CDK2, CDK4, CDK6 and cyclin-E but not CDKN1A, CDKN1B or cyclin-A. Promotes cell proliferation. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RPRD1B Polyclonal Antibody |
| Target | RPRD1B |
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