Rabbit Anti-RISC/AGO2 Polyclonal Antibody
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产品编号
PAV3380
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别名
argonaute RISC catalytic component 2, CASC7, EIF2C2, LESKRES, LINC00980, PPD, Q10
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | argonaute RISC catalytic component 2, CASC7, EIF2C2, LESKRES, LINC00980, PPD, Q10 |
| Catalog Number | PAV3380 |
| Product Description | Rabbit polyclonal antibody raised against human AGO2 (Protein argonaute-2). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | AGO2 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录与RNA加工 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009] |
| Immunogen | This antibody was raised against from part region of human AGO2 protein (UniProt: Q9UKV8) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 27161 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈97.2 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 97.2 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q9UKV8 |
| Note | Gene ID: 27161; UniProt: Q9UKV8; Chromosome: 8q24.3; Predicted MW: 97.2 kDa |
| Function | Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human AGO2 Polyclonal Antibody |
| Target | AGO2 |
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