Rabbit Anti-PRP8/PRPF8 Polyclonal Antibody

产品编号

PAV3166

别名

pre-mRNA processing factor 8, HPRP8, PRP8, PRPC8, RP13, SNRNP220

目录价格

InquiryRMB

规格

100ul

DATASHEET COA

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产品介绍

Alias	pre-mRNA processing factor 8, HPRP8, PRP8, PRPC8, RP13, SNRNP220
Catalog Number	PAV3166
Product Description	Rabbit polyclonal antibody raised against human PRPF8 (Pre-mRNA-processing-splicing factor 8). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: IHC-p. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	PRPF8
Species	Human, Mouse
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	转录与RNA加工
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	Pre-mRNA splicing occurs in 2 sequential transesterification steps. The protein encoded by this gene is a component of both U2- and U12-dependent spliceosomes, and found to be essential for the catalytic step II in pre-mRNA splicing process. It contains several WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp8 protein. This gene is a candidate gene for autosomal dominant retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Immunogen	This antibody was raised against from part region of human PRPF8 protein (UniProt: Q6P2Q9)
Application	IHC-p
Recommended Dilution	IHC-p 1:50-200
Gene ID	10594
Tag	Unconjugated
Cross-reactivity	Human, Mouse
Predicted Molecular Weight	≈273.6 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	273.6 kDa
Cross-reactivity	Human, Mouse
Uniprot ID	Q6P2Q9
Note	Gene ID: 10594; UniProt: Q6P2Q9; Chromosome: 17p13.3; Predicted MW: 273.6 kDa
Function	Plays a role in pre-mRNA splicing as core component of precatalytic, catalytic and postcatalytic spliceosomal complexes, both of the predominant U2-type spliceosome and the minor U12-type spliceosome. Functions as a scaffold that mediates the ordered assembly of spliceosomal proteins and snRNAs. Required for the assembly of the U4/U6-U5 tri-snRNP complex, a building block of the spliceosome. Functions as a scaffold that positions spliceosomal U2, U5 and U6 snRNAs at splice sites on pre-mRNA substrates, so that splicing can occur. Interacts with both the 5' and the 3' splice site.
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human PRPF8 Polyclonal Antibody
Target	PRPF8