Rabbit Anti-PIWL2/PIWIL2 Polyclonal Antibody
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产品编号
PAV3049
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别名
piwi like RNA-mediated gene silencing 2, CT80, HILI, PIWIL1L, mili
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | piwi like RNA-mediated gene silencing 2, CT80, HILI, PIWIL1L, mili |
| Catalog Number | PAV3049 |
| Product Description | Rabbit polyclonal antibody raised against human PIWIL2 (Piwi-like protein 2). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | PIWIL2 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录与RNA加工 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | PIWIL2 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells (Sasaki et al., 2003 [PubMed 12906857]).[supplied by OMIM, Mar 2008] |
| Immunogen | This antibody was raised against from part region of human PIWIL2 protein (UniProt: Q8TC59) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 55124 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈109.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 109.8 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q8TC59 |
| Note | Gene ID: 55124; UniProt: Q8TC59; Chromosome: 8p21.3; Predicted MW: 109.8 kDa |
| Function | Endoribonuclease that plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity (By similarity). Plays an essential role in meiotic differentiation of spermatocytes, germ cell differentiation and in self-renewal of spermatogonial stem cells (By similarity). Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons (By similarity). During piRNA biosynthesis, plays a key role in the piRNA amplification loop, also named ping-pong amplification cycle, by acting as a 'slicer-competent' piRNA endoribonuclease that cleaves primary piRNAs, which are then loaded onto 'slicer-incompetent' PIWIL4 (By similarity). PIWIL2 slicing produces a pre-miRNA intermediate, which is then processed in mature piRNAs, and as well as a 16 nucleotide by-product that is degraded (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human PIWIL2 Polyclonal Antibody |
| Target | PIWIL2 |
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