Rabbit Anti-MBNL3 Polyclonal Antibody
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产品编号
PAV2256
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别名
muscleblind like splicing regulator 3, CHCR, MBLX, MBLX39, MBXL
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | muscleblind like splicing regulator 3, CHCR, MBLX, MBLX39, MBXL |
| Catalog Number | PAV2256 |
| Product Description | Rabbit polyclonal antibody raised against human MBNL3 (Muscleblind-like protein 3). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | MBNL3 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 转录与RNA加工 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a member of the muscleblind-like family of proteins. The encoded protein may function in regulation of alternative splicing and may play a role in the pathophysiology of myotonic dystrophy. Alternatively spliced transcript variants have been described. [provided by RefSeq, Dec 2009] |
| Immunogen | This antibody was raised against from part region of human MBNL3 protein (UniProt: Q9NUK0) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 55796 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈38.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 38.5 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9NUK0 |
| Note | Gene ID: 55796; UniProt: Q9NUK0; Chromosome: Xq26.2; Predicted MW: 38.5 kDa |
| Function | Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. May play a role in myotonic dystrophy pathophysiology (DM). Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human MBNL3 Polyclonal Antibody |
| Target | MBNL3 |
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