Rabbit Anti-STB5L/STXBP5L Polyclonal Antibody
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产品编号
PAV3849
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别名
syntaxin binding protein 5L, LLGL4
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | syntaxin binding protein 5L, LLGL4 |
| Catalog Number | PAV3849 |
| Product Description | Rabbit polyclonal antibody raised against human STXBP5L (Syntaxin-binding protein 5-like giant larvae protein homolog 4)). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | STXBP5L |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 突触与髓鞘 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is similar to syntaxin-binding protein 5 and contains ten N-terminal WD40 repeats, four variable region WD40 repeats, and a C-terminal R-SNARE domain. Studies of the orthologous proteins in mouse and rat have shown that the encoded protein may inhibit exocytosis in neurosecretory cells, and may negatively regulate the secretion of insulin. A missense variant in this gene is likely the cause of an infantile-onset neurodegenerative disorder diagnosed in two siblings of consanguineous parents. [provided by RefSeq, Jan 2017] |
| Immunogen | This antibody was raised against from part region of human STXBP5L protein (UniProt: Q9Y2K9) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 9515 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈131.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 131.9 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9Y2K9 |
| Note | Gene ID: 9515; UniProt: Q9Y2K9; Chromosome: 3q13.33; Predicted MW: 131.9 kDa |
| Function | Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Also plays a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation (By similarity). Promotes as well axonal outgrowth. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human STXBP5L Polyclonal Antibody |
| Target | STXBP5L |
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