Rabbit Anti-TTC5 Polyclonal Antibody
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产品编号
PAV4179
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别名
tetratricopeptide repeat domain 5, NEDCAFD, Strap
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | tetratricopeptide repeat domain 5, NEDCAFD, Strap |
| Catalog Number | PAV4179 |
| Product Description | Rabbit polyclonal antibody raised against human TTC5 (Tetratricopeptide repeat protein 5). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | TTC5 |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 小G蛋白与适配蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables ribosome binding activity. Involved in positive regulation of mRNA catabolic process. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025] |
| Immunogen | This antibody was raised against from part region of human TTC5 protein (UniProt: Q8N0Z6) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 91875 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈48.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 48.9 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q8N0Z6 |
| Note | Gene ID: 91875; UniProt: Q8N0Z6; Chromosome: 14q11.2; Predicted MW: 48.9 kDa |
| Function | Cofactor involved in the regulation of various cellular mechanisms such as actin regulation, autophagy, chromatin regulation and DNA repair. In non-stress conditions, interacts with cofactor JMY in the cytoplasm which prevents JMY's actin nucleation activity and ability to activate the Arp2/3 complex. Acts as a negative regulator of nutrient stress-induced autophagy by preventing JMY's interaction with MAP1LC3B, thereby preventing autophagosome formation (By similarity). Involves in tubulin autoregulation by promoting its degradation in response to excess soluble tubulin. To do so, associates with the active ribosome near the ribosome exit tunnel and with nascent tubulin polypeptides early during their translation, triggering tubulin mRNA-targeted degradation. Following DNA damage, phosphorylated by DNA damage responsive protein kinases ATM and CHEK2, leading to its nuclear accumulation and stability. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human TTC5 Polyclonal Antibody |
| Target | TTC5 |
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