Rabbit Anti-RHG24/ARHGAP24 Polyclonal Antibody
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产品编号
PAV3362
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别名
Rho GTPase activating protein 24, FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | Rho GTPase activating protein 24, FILGAP, RC-GAP72, RCGAP72, p73, p73RhoGAP |
| Catalog Number | PAV3362 |
| Product Description | Rabbit polyclonal antibody raised against human ARHGAP24 (Rho GTPase-activating protein 24). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | ARHGAP24 |
| Species | Human, Rat, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 小G蛋白与适配蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016] |
| Immunogen | This antibody was raised against from part region of human ARHGAP24 protein (UniProt: Q8N264) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 83478 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat, Mouse |
| Predicted Molecular Weight | ≈84.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 84.3 kDa |
| Cross-reactivity | Human, Rat, Mouse |
| Uniprot ID | Q8N264 |
| Note | Gene ID: 83478; UniProt: Q8N264; Chromosome: 4q21.23-q21.3; Predicted MW: 84.3 kDa |
| Function | Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human ARHGAP24 Polyclonal Antibody |
| Target | ARHGAP24 |
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