Rabbit Anti-RELN Polyclonal Antibody
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产品编号
PAV3317
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别名
reelin, ETL7, LIS2, PRO1598, RL
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | reelin, ETL7, LIS2, PRO1598, RL |
| Catalog Number | PAV3317 |
| Product Description | Rabbit polyclonal antibody raised against human RELN (Reelin). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: IHC-p. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RELN |
| Species | Human, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 小G蛋白与适配蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a large secreted extracellular matrix protein thought to control cell-cell interactions critical for cell positioning and neuronal migration during brain development. This protein may be involved in schizophrenia, autism, bipolar disorder, major depression and in migration defects associated with temporal lobe epilepsy. Mutations of this gene are associated with autosomal recessive lissencephaly with cerebellar hypoplasia. Two transcript variants encoding distinct isoforms have been identified for this gene. Other transcript variants have been described but their full length nature has not been determined. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human RELN protein (UniProt: P78509) |
| Application | IHC-p |
| Recommended Dilution | IHC-p 1:50-200 |
| Gene ID | 5649 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat |
| Predicted Molecular Weight | ≈388.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 388.4 kDa |
| Cross-reactivity | Human, Rat |
| Uniprot ID | P78509 |
| Note | Gene ID: 5649; UniProt: P78509; Chromosome: 7q22.1; Predicted MW: 388.4 kDa |
| Function | Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RELN Polyclonal Antibody |
| Target | RELN |
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