Rabbit Anti-RBP10/RANBP10 Polyclonal Antibody

产品编号

PAV3306

别名

RAN binding protein 10

目录价格

InquiryRMB

规格

100ul

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产品介绍

Alias	RAN binding protein 10
Catalog Number	PAV3306
Product Description	Rabbit polyclonal antibody raised against human RANBP10 (Ran-binding protein 10). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml.
Molecular Name	RANBP10
Species	Human
Host	Rabbit
Size	100ul
Clonity	Polyclonal
Protein Family	小G蛋白与适配蛋白
Concentration	1 mg/ml
Purification	affinity-chromatography
Formulation	supply in PBS containing 50% glycerol, and 0.02% sodium azide.
Background	RAN is a small GTPase involved in the assembly of microtubules to form mitotic spindles. The protein encoded by this gene is a cytoplasmic guanine nucleotide exchange factor (GEF) that binds beta-tubulin and has GEF activity toward RAN. The encoded protein plays a role in the formation of noncentrosomal microtubules. In addition, this protein may be involved in the regulation of D(1) receptor signaling by protein kinase C delta and protein kinase C gamma. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
Immunogen	This antibody was raised against from part region of human RANBP10 protein (UniProt: Q6VN20)
Application	WB, ELISA
Recommended Dilution	WB 1:500-2000 ELISA 1:5000-20000
Gene ID	57610
Tag	Unconjugated
Cross-reactivity	Human
Predicted Molecular Weight	≈67.3 kDa
Storage Condition	Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles.
Shipping Condition	This product is shipped on blue ice.
Molecular Weight	67.3 kDa
Cross-reactivity	Human
Uniprot ID	Q6VN20
Note	Gene ID: 57610; UniProt: Q6VN20; Chromosome: 16q22.1; Predicted MW: 67.3 kDa
Function	May act as an adapter protein to couple membrane receptors to intracellular signaling pathways (Probable). Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen-induced transactivation. Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase. May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity).
Product Declaration	本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。
Product Full Name	Rabbit Anti-Human RANBP10 Polyclonal Antibody
Target	RANBP10