Rabbit Anti-RB40C/RAB40C Polyclonal Antibody
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产品编号
PAV3292
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别名
RAB40C, member RAS oncogene family, RARL, RASL8C
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | RAB40C, member RAS oncogene family, RARL, RASL8C |
| Catalog Number | PAV3292 |
| Product Description | Rabbit polyclonal antibody raised against human RAB40C (Ras-related protein Rab-40C). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RAB40C |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 小G蛋白与适配蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables G protein activity and ubiquitin-like ligase-substrate adaptor activity. Involved in several processes, including lipid droplet formation; negative regulation of focal adhesion assembly; and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in Golgi membrane; cytosol; and lipid droplet. Part of Cul5-RING ubiquitin ligase complex. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human RAB40C protein (UniProt: Q96S21) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 57799 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈31.3 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 31.3 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q96S21 |
| Note | Gene ID: 57799; UniProt: Q96S21; Chromosome: 16p13.3; Predicted MW: 31.3 kDa |
| Function | RAB40C small GTPase acts as substrate-recognition component of the ECS(RAB40C) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The Rab40 subfamily belongs to the Rab family that are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. As part of the ECS(RAB40C) complex, mediates ANKRD28 ubiquitination and degradation, thereby inhibiting protein phosphatase 6 (PP6) complex activity and focal adhesion assembly during cell migration. Also negatively regulate lipid droplets accumulation in a GTP-dependent manner. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RAB40C Polyclonal Antibody |
| Target | RAB40C |
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