Rabbit Anti-RB39A/RAB39A Polyclonal Antibody
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产品编号
PAV3289
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别名
RAB39A, member RAS oncogene family, K28, RAB39
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | RAB39A, member RAS oncogene family, K28, RAB39 |
| Catalog Number | PAV3289 |
| Product Description | Rabbit polyclonal antibody raised against human RAB39A (Ras-related protein Rab-39A). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RAB39A |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 小G蛋白与适配蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | Enables G protein activity. Involved in autophagosome-lysosome fusion; phagosome acidification; and phagosome-lysosome fusion. Located in autolysosome membrane and phagocytic vesicle. [provided by Alliance of Genome Resources, Jun 2026] |
| Immunogen | This antibody was raised against from part region of human RAB39A protein (UniProt: Q14964) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 54734 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈25.0 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 25.0 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q14964 |
| Note | Gene ID: 54734; UniProt: Q14964; Chromosome: 11q22.3; Predicted MW: 25.0 kDa |
| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB39A regulates autophagosome-lysosome fusion via recruitment of the HOPS endosomal tethering complex onto lysosomes; this process involves lysosomal RAB39A and autophagosomal RAB2A recruitment of HOPS subcomplexes VPS41-VPS16-VPS18-VPS33A and VPS39-VPS11, respectively, which assemble into a functional complex to mediate membrane tethering and SNAREs-driven membrane fusion. Also negatively regulates lipopolysaccharide (LPS)-induced autophagosome formation in macrophages, possibly by implicating PI3K. Promotes the delivery of MHC-I molecules from the ER to phagosomes and the generation of peptide-loaded MHC-I complexes in phagosomes, thus enhancing antigen cross-presentation by dendritic cells (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RAB39A Polyclonal Antibody |
| Target | RAB39A |
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