Rabbit Anti-RASA1 Polyclonal Antibody
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产品编号
PAV3276
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别名
RAS p21 protein activator 1, CM-AVM, CMAVM, CMAVM1, GAP, PKWS, RASA, RASGAP, p120
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | RAS p21 protein activator 1, CM-AVM, CMAVM, CMAVM1, GAP, PKWS, RASA, RASGAP, p120 |
| Catalog Number | PAV3276 |
| Product Description | Rabbit polyclonal antibody raised against human RASA1 (Ras GTPase-activating protein 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RASA1 |
| Species | H, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 小G蛋白与适配蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012] |
| Immunogen | This antibody was raised against from part region of human RASA1 protein (UniProt: P20936) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 5921 |
| Tag | Unconjugated |
| Cross-reactivity | H, Rat |
| Predicted Molecular Weight | ≈116.4 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 116.4 kDa |
| Cross-reactivity | H, Rat |
| Uniprot ID | P20936 |
| Note | Gene ID: 5921; UniProt: P20936; Chromosome: 5q14.3; Predicted MW: 116.4 kDa |
| Function | GTPase-activating protein (GAP) that stimulates the intrinsic GTPase activity of Ras proteins, such as NRAS, facilitating their transition from the active GTP-bound state to the inactive GDP-bound state, thereby terminating Ras signaling. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RASA1 Polyclonal Antibody |
| Target | RASA1 |
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