Rabbit Anti-RABX5/RABGEF1 Polyclonal Antibody
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产品编号
PAV3256
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别名
RAB guanine nucleotide exchange factor 1, RABEX5, RAP1, rabex-5
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | RAB guanine nucleotide exchange factor 1, RABEX5, RAP1, rabex-5 |
| Catalog Number | PAV3256 |
| Product Description | Rabbit polyclonal antibody raised against human RABGEF1 (Rab5 GDP/GTP exchange factor). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | RABGEF1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 小G蛋白与适配蛋白 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor (GEF) for RAB5 (RAB5A; MIM 179512) (Horiuchi et al., 1997 [PubMed 9323142]).[supplied by OMIM, Mar 2010] |
| Immunogen | This antibody was raised against from part region of human RABGEF1 protein (UniProt: Q9UJ41) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 27342 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈56.9 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 56.9 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | Q9UJ41 |
| Note | Gene ID: 27342; UniProt: Q9UJ41; Chromosome: 7q11.21; Predicted MW: 56.9 kDa |
| Function | Acts as a guanine-nucleotide releasing factor (GEF) for RAB5A by promoting the conversion of inactive RAB-GDP to the active form RAB-GTP. Forms a complex with RABEP1 that acts as Rab4/Rab5 effector regulating endosome fusion. Involved in endocytic membrane fusion and membrane trafficking of recycling endosomes. Also functions as a ubiquitin ligase (By similarity). |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human RABGEF1 Polyclonal Antibody |
| Target | RABGEF1 |
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