Rabbit Anti-TSK/ITK Polyclonal Antibody
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产品编号
PAV4163
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别名
IL2 inducible T cell kinase, EMT, LPFS1, LYK, PSCTK2
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | IL2 inducible T cell kinase, EMT, LPFS1, LYK, PSCTK2 |
| Catalog Number | PAV4163 |
| Product Description | Rabbit polyclonal antibody raised against human ITK (Tyrosine-protein kinase ITK/TSK). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | ITK |
| Species | Human, Mouse, Rat |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 蛋白激酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human ITK protein (UniProt: Q08881) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 3702 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse, Rat |
| Predicted Molecular Weight | ≈71.8 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 71.8 kDa |
| Cross-reactivity | Human, Mouse, Rat |
| Uniprot ID | Q08881 |
| Note | Gene ID: 3702; UniProt: Q08881; Chromosome: 5q33.3; Predicted MW: 71.8 kDa |
| Function | Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human ITK Polyclonal Antibody |
| Target | ITK |
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