Rabbit Anti-STK19 Polyclonal Antibody
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产品编号
PAV3853
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别名
winged helix repair factor 1, D6S60, D6S60E, G11, HLA-RP1, RP1, STK19, TWH19
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | winged helix repair factor 1, D6S60, D6S60E, G11, HLA-RP1, RP1, STK19, TWH19 |
| Catalog Number | PAV3853 |
| Product Description | Rabbit polyclonal antibody raised against human WHR1 (Winged helix repair factor 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | WHR1 |
| Species | Human, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 蛋白激酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes a serine/threonine kinase which localizes predominantly to the nucleus. Its specific function is unknown; it is possible that phosphorylation of this protein is involved in transcriptional regulation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6 and expresses two transcript variants. [provided by RefSeq, Jul 2008] |
| Immunogen | This antibody was raised against from part region of human WHR1 protein (UniProt: P49842) |
| Application | WB |
| Recommended Dilution | WB 1:500-2000 |
| Gene ID | 8859 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Mouse |
| Predicted Molecular Weight | ≈28.5 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 28.5 kDa |
| Cross-reactivity | Human, Mouse |
| Uniprot ID | P49842 |
| Note | Gene ID: 8859; UniProt: P49842; Chromosome: 6p21.33; Predicted MW: 28.5 kDa |
| Function | DNA-binding protein which is required for efficient transcription-coupled nucleotide excision repair (TC-NER). Acts as part of a TC-NER complex which assembles and interacts with RNA polymerase II (RNAPII) when it stalls at DNA lesions. TC-NER complex subunit UVSSA binds to the GTF2H1/p62 subunit of the TFIIH transcription factor complex, tethering TFIIH to the TC-NER complex. WHR1/STK19 then interacts with the XPD helicase subunit of TFIIH which guides TFIIH to DNA downstream of the stalled RNAPII, ensuring DNA repair. Directly interacts with RNAPII and also binds to downstream DNA. Promotes the timely removal of DNA damage-stalled RNAPII, allowing downstream NER factors to access DNA lesions. Required for monoubiquitination of UVSSA. Regulates repositioning and stabilization of UVSSA within the TC-NER complex. Stimulates ubiquitination of RNAPII complex member RBP1. Also binds to RNA and regulates the expression levels of many mRNAs. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human WHR1 Polyclonal Antibody |
| Target | WHR1 |
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