Rabbit Anti-SH3K1/SH3KBP1 Polyclonal Antibody
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产品编号
PAV3661
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别名
SH3 domain containing kinase binding protein 1, AGMX2, CD2BP3, CIN85, GIG10, HSB-1, HSB1, IMD61, MIG18
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目录价格
InquiryRMB
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规格
- 100ul
产品介绍
| Alias | SH3 domain containing kinase binding protein 1, AGMX2, CD2BP3, CIN85, GIG10, HSB-1, HSB1, IMD61, MIG18 |
| Catalog Number | PAV3661 |
| Product Description | Rabbit polyclonal antibody raised against human SH3KBP1 (SH3 domain-containing kinase-binding protein 1). Affinity purified from rabbit antiserum by antigen-specific affinity chromatography. Validated applications: WB, ELISA. Supplied as liquid in PBS containing 50% glycerol and 0.02% sodium azide at 1 mg/ml. |
| Molecular Name | SH3KBP1 |
| Species | Human, Rat, Mouse |
| Host | Rabbit |
| Size | 100ul |
| Clonity | Polyclonal |
| Protein Family | 蛋白激酶 |
| Concentration | 1 mg/ml |
| Purification | affinity-chromatography |
| Formulation | supply in PBS containing 50% glycerol, and 0.02% sodium azide. |
| Background | This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017] |
| Immunogen | This antibody was raised against from part region of human SH3KBP1 protein (UniProt: Q96B97) |
| Application | WB, ELISA |
| Recommended Dilution | WB 1:500-2000 ELISA 1:5000-20000 |
| Gene ID | 30011 |
| Tag | Unconjugated |
| Cross-reactivity | Human, Rat, Mouse |
| Predicted Molecular Weight | ≈73.1 kDa |
| Storage Condition | Store at 4℃ for for short term storage. It is recommended to aliquote to ~10ul per vial and store at -20℃ for long term storage. Avoid repeated freezing and thawing cycles. |
| Shipping Condition | This product is shipped on blue ice. |
| Molecular Weight | 73.1 kDa |
| Cross-reactivity | Human, Rat, Mouse |
| Uniprot ID | Q96B97 |
| Note | Gene ID: 30011; UniProt: Q96B97; Chromosome: Xp22.12; Predicted MW: 73.1 kDa |
| Function | Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through an association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may be inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by interaction with its regulatory subunit (By similarity). May be involved in regulation of cell adhesion; promotes the interaction between TTK2B and PDCD6IP. May be involved in the regulation of cellular stress response via the MAPK pathways through its interaction with MAP3K4. Is involved in modulation of tumor necrosis factor mediated apoptosis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. Has an essential role in the stimulation of B cell activation. |
| Product Declaration | 本产品仅用于研究用途(RUO)。不能用于诊断或直接用于人体实验。 |
| Product Full Name | Rabbit Anti-Human SH3KBP1 Polyclonal Antibody |
| Target | SH3KBP1 |
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